Our Programme: NTDs (neglected tropical diseases) are a major health and economic burden in Organisation of Islamic Cooperation (OIC) member states. The control and elimination of NTDs requires both a scale-up and integration of global mass treatment programmes, along with new tools and technologies to tackle these diseases. COMSTECH, in collaboration with A Global Network for Neglected Tropical Diseases (known as the NTD Network, https://ntd-network.org/), is launching a virtual lecture series. for researchers across the Moslem world and beyond. Our programme draws upon expertise from both networks, and offers opportunities to gain or enhance researcher knowledge, skills and connections, all of which help to grow our shared global capacity to tackle these rapidly growing NTDs.
The NTD Network, funded by UKRI’s Global Challenges Research Fund (GCRF), is a consortium of academic researchers from South America, Asia, and the UK, seeking new therapeutic solutions to leishmaniasis and Chagas disease
Both COMSTECH and the NTD Network aim to promote global scientific cooperation and build researcher capacity to find new and better therapeutic solutions for NTDs
This online programme is the first of many COMSTECH-NTD Network joint activities via the COMSTECH platform.
Target Audience: This webinar is open to academics, scientists and the general public from all OIC member states. The content is most relevant to scientists interested in NTDs research, and specialised in Microbiology, Genetics, Genomics, Molecular Biology, Molecular Medicine, and Pathology.
Abstract: We give a preliminaries from biology about free and bisexual populations. Considering several mathematical models of biological and physical dynamical systems we discuss their time and temperature depending behaviors. Moreover, some open problems will be discussed.
Target Audience: This webinar is open to academicians, scientists, and general public from all the member OIC states and beyond.
Profile of the Speakers: Rozikov is an internationally renowned expert in probability, mathematical physics and analysis, specializing in dynamical systems and statistical mechanics on graphs. His prizes and fellowships include prize of TWAS for Young Scientists; TWAS Young Affiliate; TWAS Research Grant; Prize of Japan Embassy in Tashkent; Medal “Uzbekiston Belgisi”, Uzbekistan; Fellowship of IHES, France; NATO Reintegration Grant; The Royal Society grant, Cambridge, UK; Medal “The excellent teacher” of Uzbekistan; CNR-Fellowship grant of Italian CNR; Junior Associate of ICTP, Italy.
Rozikov is an exceptionally prolific author: since 1995, he has published over 150 papers in top journals including 12(!) papers in the flagship Journal of Statistical Physics (Impact Factor 1.202), 23(!) papers in Theoretical and mathematical Physics and also in Lett. Math. Phys. (1.939), Comm. Math. Phys. (2.086), J. Stat. Mech. Theory Exp. (2.404), J. Math. Anal. Appl. (1.120), etc. In particular, in 2013 he published an extensive review paper (112 pages) in Rev. Math. Phys. (1.329), followed by 4 (four) research monographs.
(Professor Solid State & Structural Chemistry Unit, Indian Institute of Science,
Bangalore, India
Winner of Alexander von Humboldt Forschungspreis, and the TWAS award
Date and Time: 11th August, 2021; 3:00 PM PKT
Abstract:
A field that was defined 30 years ago as “the understanding of intermolecular interactions in the context of crystal packing and in the utilization of such understanding in the design of new solids with desired physical and chemical properties”, and which has been identified as the central issue in structure design. The lack of a direct correspondence between molecular and crystal structure in the sequence “One → Few → Many → Nucleus → Crystal”, has now evolved into “an area of virtually unlimited scope where science funding and translation efforts could be directed in the current climate of a society that increasingly expects applications and utility products from science and technology”. Certain current concerns will be addressed in this talk.
Target Audience:
This webinar is open to academicians, scientists, and general public from all the OIC member states.
Profile of Speaker:
Prof. Dr. Gautam Desiraju’s work is in the subject of Crystal Engineering. He has made seminal, wide-ranging and original contributions at the top-most international level. Prof. Dr. Desiraju has developed and nurtured the subject into a modern, competitive area. He is well noted for gaining acceptance for the theme of weak hydrogen bonding among chemists and crystallographers. Through his now classical book “ Crystal Engineering, The Design of Organic Solids (Elsevier, 1989), he showed that this is a subject of vast scope. His outstanding and prolific academic record amounts at present to 475 research papers, three authored books and three edited books. Prof. Dr. Desiraju is cited nearly 50000 times in SCI journals and books, with an h-index of 90 (Web of Science), placing him among the most cited scientists in India today. He was a member of the IUPAC committee responsible for producing a modern official definition of this important intermolecular interaction (2011). He has won international awards such as the Alexander von Humboldt Forschungspreis and the TWAS award in Chemistry and was awarded the ISA medal for science of the University of Bologna for the year 2018. Dr Desiraju is a former President of the International Union of Crystallography. He is a recipient of an honorary doctorate degree of the Universidad Nacional de Córdoba, Argentina and of the Rayalaseema University, Kurnool. Presently he is a member of the editorial advisory boards of Angewandte Chemie, Chemical Communications and Journal of the American Chemical Society.
(MBBS, MD, Naturopath MD, Nutritionist CNC, RMP Consultant Honorary Consul of Papua New Guinea in Pakistan)
Date and Time:June 30th, 2021; 3:00 PM PKT
Abstract:
Addressing the regional disease burden brought on by a cultural and economic shift in South Asia by providing Integrative Medical solutions based on area specific demands and needs. A dissection of the most pressing concerns in health care in South Asian countries and proposed solutions to mitigate educational and infrastructural shortcomings through a bolstering of education that encourages capacity building in healthcare professionals and education in the general populations.
Target Audience:
This webinar is open to academicians, scientists, and general public from all the member OIC states.
Profile of Speaker:
Dr. Mobashir Ahmed Bhatti is a medical doctor, who devotes his efforts to the need of forming an international team of Professionals to work as a Research and Development Group in compiling evidence-based empirical data that irrefutably establishes and documents global health issues. To encounter the health crises in third world countries, with a focus to heal humanity through integrative medical solutions and support entrepreneurs in medical field to make them successful tools for any given country.
After completing his medical education, he achieved the following to excel his Integrative Medicine Business:
Naturopath-MD,
Certified Nutritional Consultant,
Master in Business Administration (MBA)
Dr. Bhatti is the founding president of Pakistan Association Integrative Medicine and executive coaching lead for South Asian Academy of Physicians and Surgeons. He has worked in over a dozen countries setting up leadership, product, research and alliance teams. As a leadership and team development expert, now he is focused specially on health care sector.
Abstract: Tankyrases (TNKSs) are members of the poly(ADP-ribose)-polymerase (PARP) family of seventeen enzymes that use NAD+ as a source of ADP-ribose units to attach to target proteins as a regulatory post-translational modification. Target proteins of the two tankyrases include telomere repeating binding factor-1 (TRF1), nuclear mitotic apparatus protein (NuMA) (essential for separation of chromatids in cell division) and axin (a major component of Wnt / b-catenin signalling). Inhibition of TNKSs is reported to lead to decreased proliferation of cancer cells. The axin−TNKS−KIF3A complex is needed for insulin-stimulated translocation of GLUT4 to the cell membrane. Insulin-regulated amino-peptidase (IRAP) is also a binding partner and target protein of TNKSs. Thus inhibition of TNKSs should enhance insulin-stimulated exocytosis of GLUT4, leading to increased uptake of glucose in peripheral tissues, important in the management of diabetes.
This lecture will describe the story of how my group, with important external collaborations, explored the NAD+-binding site of the tankyrases through design, synthesis and biochemical evaluation of several series of isoquinolin-1-ones, quinazolin-4-ones, naphthyridinones, pyridopyrimidinones and related compounds. Crystal structures of several of these inhibitors, along with Structure-Activity Relationship studies, allowed detailed understanding of the shape and properties of the nicotinamide-binding pocket. NAD+ is also a substrate for many other enzymes in mammalian cells, including oxidoreductases and the other PARPs; thus the selectivity of inhibitors is important. These studies also led to an understanding of the structural basis for selectivity of inhibition of tankyrases vs. PARP1. Further elaboration of the core structure culminated in identification of two “dual-site” inhibitors binding at both the nicotinamide-binding pocket and at the adenosine-binding pocket. These final designed inhibitors showed exquisite potency (IC50vs. tankyrase-2 100 pM) and selectivity (65000× selective for tankyrase-2 vs. PARP1).
Target Audience: This webinar is open to academicians, scientists, and general public from all the member OIC states and beyond.
Research Interest of speaker: The research focus of the Threadgill group is drug design and delivery. We work on the application of medicinal chemistry (structure-based drug design, chemical synthesis, biochemical and cell biological evaluation) to developing new cancer treatments. Where the biochemistry of other diseases is similar (haemorrhagic shock, stroke, myocardial infarction, etc.), our work has branched out into these areas. We also research new synthetic methods in organic heterocyclic chemistry. Collaborations in Bath, Aberystwyth, Finland, India and Poland are important to our work.
To explore the topic of tropical medicine and natural products, Indonesian Institute of Sciences (LIPI) in collaboration with COMSTECH (OIC Standing Committee on Scientific and Technological Cooperation) will conduct an International Workshop on “Tropical Medicine and Natural Product” on 2nd June, 2021. This workshop will be divided into 2 sessions to discuss about biodiversity exploration for traditional medicine and natural products, and also natural products and industrial applications. Furthermore, we are also expecting potential collaboration between countries, especially OIC member states to conduct research related to tropical medicines and natural products for the treatment of communicable and non-communicable diseases.
As a OIC member state, Indonesia is currently developing potential vaccine candidates. The vaccine, Vaksin Merah Putih, developed jointly National Research and Innovation Agency, Ministry of Health, Bio Farma, Eijkman, and universities in Indonesia. Along with vaccine development, many research institutions in Indonesia are working on compounds from herbal ingredients that have the potential to treat Covid-19. Based on the research that has been done, some local Indonesian plants are predicted to be candidates for COVID-19 inhibitors. Previously, Indonesian Institute of Sciences (LIPI) had found Immunomodulator, an immune-enhancing supplement derived from red ginger, Cordyceps, Sambiloto, meniran and sembung leaves. This herbal medicine is medicinal and increases the body’s immune system to fight viral infections. Immunomodulators have been tested at the Emergency Hospital for Covid-19, Wisma Atlet Kemayoran, Jakarta on June 8, 2020.
Natural products from plants, marine organisms, and microorganisms, are the richest source of drug candidates. Currently over 40% of clinically used drugs have natural origin. Nature is the sustainable source of biologically active molecules, and recent developments in chromatography and spectroscopic techniques made it possible to fully utilize their potential. This COMSTECH-LIPI joint workshop is aimed to discuss most recent developments in this field, and to foster productive collaboration between the researchers in OIC member states.
B.Objectives
To identify and explore the biodiversity potential of traditional medicine and natural product in health and disease management.
To encourage and strengthen collaboration among OIC member states in research, innovation, and development of various therapeutic products.
To provide affordable biotechnology products for OIC member states.
C. Speakers and Moderator
Speaker
Dr. Laksana Tri Handoko, Chairman of National Research and Innovation Agency (BRIN)
Prof. Dr. M. Iqbal Choudhary, Coordinator General COMSTECH as well as a Director ICCBS – Pakistan
Prof. Dr. Ibrahim Jantan, Universiti Kebangsaan Malaysia
Prof. Dr. Andria Agusta, Research Center for Chemistry, Indonesian Institute of Sciences (LIPI)
Mr. Kilala Tilaar, CEO of Martha Tilaar Group
Dr. Nadeem Khalid (CEO at Herbion Pakistan)
Prof. Dr. Edi Meiyanto, Gadjah Mada University (UGM)
Moderator
Dr. Delicia Yunita Rahman, Research Center for Biotechnology, Indonesian Institute of Sciences (LIPI)
Dr. Anggia Presetyoputri, Research Center for Biotechnology, Indonesian Institute of Sciences (LIPI)
D.Participants
Open for public, this international workshop is targeted to be attended by OIC member state, researchers, academia, related Ministries/Institutions, Universities, Media and general public.
E. Date and Venue
The webinar will be held on Wednesday, 2 June 2020, 09.00-12.35 PST Time and/or 11.00-14.35 GMT +7 via Zoom meeting and YouTube Live Streaming on COMSTECH & LIPI channel
COMSTECH – LIPIInternational Webinar on Tropical Medicine and Natural Products
09.00 AM PST/11.00 AM IDN, June 2nd, 2021
TIME
Duration (min)
PROGRAMS
FACILITATOR
09.00 – 09.05 AM PST 11.00 – 11.05 AM IDN
5
Opening & Greetings by MC
MC
09.05 – 09.15 AM PST 11.05 – 11.15 AM IDN
10
Welcome Remarks by Coordinator General COMSTECH, Director ICCBS – Pakistan
Prof. Dr. M. Iqbal Choudhary
09.15 – 09.25 AM PST 11.15 – 11.25 AM IDN
10
Opening Remarks by Chairman of BRIN
Dr. Laksana Tri Handoko
09.25 – 09.30 AM PST 11.25 – 11.30 AM IDN
5
Introduction of the Presentation Session by Moderator
Moderator: Dr. Anggia Prasetyoputri (LIPI)
09.30 – 11.00 AM PST 11.30 – 13.00 PM IDN
90
Topic 1: Biodiversity Exploration for Traditional Medicines and Natural Products Speaker 1: Prof. M. Iqbal Choudhary Speaker 2: Prof. Ibrahim Jantan Speaker 3: Prof. Andria Agusta
Prof. Dr. M. Iqbal Choudhary (Coordinator General COMSTECH, Director ICCBS – University of Karachi, Pakistan) Prof. Dr. Ibrahim Jantan (Universiti Kebangsaan Malaysia) Prof. Andria Agusta (LIPI)
11.00 – 11.05 AM PST 13.00 – 13.05 PM IDN
5
Introduction of the Presentation Session by Moderator
Moderator: Dr. Delicia Yunita Rahma (LIPI)
11.05 – 12.35 PM PST 13.05 – 14.35 PM IDN
90
Topic 2: Natural Products and Industrial Applications Speaker 1: Dr. Nadeem Khalid Speaker 2: Mr. Kilala Tilaar Speaker 3: Prof. Edi Meiyanto
Dr. Nadeem Khalid (CEO at Herbion Pakistan) Mr. Kilala Tilaar Prof. Dr. Edi Meiyanto (UGM)
